We present the case of a 53-year-old patient with an orthotopic liver transplant performed in May 2025 for liver cirrhosis of viral etiology (hepatitis B+D), with a history of antiviral treatment failure after multiple courses (interferon, ribavirin, entecavir), also presenting a dysplastic hepatic nodule. Associated comorbidities include insulin-dependent type 2 diabetes mellitus, arterial hypertension, splenic artery pseudoaneurysm, and hypothyroidism secondary to chronic autoimmune thyroiditis, managed with levothyroxine replacement therapy.